The cannabinoids effect on bone formation and bone healing

B Raphael-Mizrahi, Y Gabet - Current Osteoporosis Reports, 2020 - Springer
Cannabinoid receptors CB1 and CB2 are expressed in bone and regulate … between the
effect of CB1 and CB2 activation reported using genetically modified animal models. Studies on …

Bones and joints: the effects of cannabinoids on the skeleton

J Ehrenkranz, MA Levine - … Clinical Endocrinology & Metabolism, 2019 - academic.oup.com
receptors type 1 (CB1) and type 2 (CB2) (3); transient … no changes in biomechanical
characteristics of femoral bones of … , can influence the effects of cannabinoid receptor signaling on …

Association of cannabinoid receptor modulation with normal and abnormal skeletal remodelling: A systematic review and meta-analysis of in vitro, in vivo and human …

A Sophocleous, M Yiallourides, F Zeng… - Pharmacological …, 2022 - Elsevier
… of Cannabis sativa has been implicated in changes in bone … precursor cells by suppressing
cannabinoid receptor type 2. … We observed that genetic inactivation of CB1 receptors in …

[HTML][HTML] The role of cannabinoids in bone metabolism: a new perspective for bone disorders

F Saponaro, R Ferrisi, F Gado, B Polini, A Saba… - International Journal of …, 2021 - mdpi.com
… on the action of the cannabinoid receptor ligands in skeleton … receptor type 2 (CB2R), which
were isolated and cloned only … in bone by modifying OB and OC differentiation and actions. …

Global cannabinoid receptor 1 deficiency affects disuse-induced bone loss in a site-specific and sex-dependent manner

RC DeNapoli, EG Buettmann, MA Friedman… - Journal of …, 2023 - Elsevier
bone metabolism; however, little is known as to how CB1 and … will also determine changes
in expression of genes and what … The type 2 cannabinoid receptor regulates bone mass and …

Impact of the endocannabinoid system on murine cranial and alveolar bone phenotype

M Setiawan, A Jäger, N Daratsianos, S Reimann… - Annals of Anatomy …, 2020 - Elsevier
… are significantly modulated by cannabinoid receptors in oral … and/or the construct used
for gene mutation with an effecting … perception of potential changes aroused by CB1 or CB2 …

Cannabinoid receptors in osteoporosis and osteoporotic pain: a narrative update of review

J Wang, H Lu, J Wang - Journal of Pharmacy and Pharmacology, 2019 - academic.oup.com
… tissue, and these changes put patients in risk of bone fracture… important role in regulating
bone metabolism and therefore in … of CB1 and CB2 receptor gene can enhance the bone mass

[图书][B] Environmental and Genetic Factors Affecting Bone Diseases and Phenotypes in Mouse Models

W Dong - 2021 - search.proquest.com
… -deficient diet enhanced the length of femur and tibia bones (… cannot distinguish the changes
in bone mass, trabecular structure… type 2 receptor (Cnr2). BCP selectively binds to Cnr2 and …

[HTML][HTML] Components of the endocannabinoid system and effects of cannabinoids against bone diseases: a mini-review

Y Xin, A Tang, S Pan, J Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
… CB2 receptor agonists increased bone mass by enhancing the … by CB1 receptor antagonists,
indicating that CB1 receptor … An eCB deficiency may affect the skeletal system. No CB …

[HTML][HTML] The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement

D Fan, H Zhai, Y Zhao, X Qiao, D Zhu, HJ Liu, C Liu - BMC Oral Health, 2024 - Springer
… Tooth displacement, alveolar bone mass and alveolar bone … BL/6 J background as a model
of the Cnr2 gene deletion. We … in well-described changes in alveolar bone quality, osteoclast/…